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Jeff Miller asked . 2022-07-15

Error when using fitrm - Fit Repeated Measures Model for RM ANOVA

I am trying to perform repeated measures ANOVA using the fitrm function, but keep getting the following error:

 

      *Error using eig*
      *Input matrix contains NaN or Inf.*
I've created a minimal working example based on the Matlab documentation for fitrm, but with some of my own variables (my actual list of measurements is much longer). I am trying to determine if the measurements from the 4 participants can be considered as statistically equivalent, while preserving the relationship between the data points (so all L1 data was collected at location 1 for all participants, L2 was collected at location 2, etc).
 
Here is my minimal example code (including data):
 
    % Data collected from 4 participants in 3 locations. 
    % Each row is a participant, each column is a location
    measurements = [  112.7258   92.2979   82.5488;
      123.7502  113.2852   84.8053;
      106.8964   93.9526   70.9359;
      107.3634   85.2672   65.7928]

    P_Name = ['A' 'B' 'C' 'D']' % participant name

    %Create a table, Data comes first, Variable names second
    t = table(P_Name,measurements(:,1),measurements(:,2),measurements(:,3),'VariableNames',{'Participant','L1','L2','L3'})

    % Create a location variable for the measurements
    Location = table([1 2 3]','VariableNames',{'Location'})

    % Fit repeated measures model
    rm = fitrm(t,'L1-L3~Participant','WithinModel',Location)

Any help is greatly received.

fitrm , anova, statistics , repeated measures , AI, Data Science, and Statistics , Statistics and M

Expert Answer

Neeta Dsouza answered . 2025-03-27 15:44:18

The error you're encountering typically occurs when there are missing (NaN) or infinite (Inf) values in the input data matrix, which prevents MATLAB from calculating eigenvalues as part of the statistical analysis.

Here are some steps to help you troubleshoot and resolve the issue:

1. Check Your Data for NaN or Inf Values

Before using the fitrm function, ensure your data does not contain missing or infinite values. You can check your data table as follows:

 

% Check for NaN or Inf in your data
any(isnan(table2array(yourTable)), 'all')  % Replace 'yourTable' with your data table
any(isinf(table2array(yourTable)), 'all')

If these checks return true, it means your data contains problematic values. You can either remove or impute these values, depending on the situation.

2. Verify Data Table Format

Ensure your data is formatted correctly for fitrm. Typically, the data should be in a table where:

  • Each row represents a participant.
  • Columns include the repeated measures and any between-subject variables.

For example:

data = table(...
    {'P1'; 'P2'; 'P3'; 'P4'}, ...
    [1.2, 1.3, 1.4, 1.5]', ...
    [2.1, 2.3, 2.5, 2.6]', ...
    [3.4, 3.6, 3.8, 4.0]', ...
    [4.5, 4.7, 4.8, 5.0]', ...
    'VariableNames', {'Participant', 'L1', 'L2', 'L3', 'L4'});

3. Define the Model Correctly

Make sure your formula for fitrm matches your data. For example:

rm = fitrm(data, 'L1-L4 ~ 1', 'WithinDesign', table([1; 2; 3; 4], 'VariableNames', {'Location'}));

4. Debugging Example

Here's a minimal example that demonstrates proper formatting:

 

% Create example data
data = table(...
    {'P1'; 'P2'; 'P3'; 'P4'}, ...
    [1.2; 1.3; 1.4; 1.5], ...
    [2.1; 2.3; 2.5; 2.6], ...
    [3.4; 3.6; 3.8; 4.0], ...
    [4.5; 4.7; 4.8; 5.0], ...
    'VariableNames', {'Participant', 'L1', 'L2', 'L3', 'L4'});

% Define within-subjects factors
within = table({'L1'; 'L2'; 'L3'; 'L4'}, 'VariableNames', {'Location'});

% Fit repeated measures model
rm = fitrm(data, 'L1-L4 ~ 1', 'WithinDesign', within);

% Display results
ranova(rm)

5. Inspect the Output

After running the above example, verify that no errors occur. If this works but your original data fails, you can iteratively compare the two to identify the issue.

6. Additional Notes

  • If your actual data has a much longer list of measurements, ensure the column names follow MATLAB's naming conventions (e.g., no special characters).
  • If you need to handle missing data, consider replacing NaN values with group means or other imputation methods before fitting the model.

If you're still encountering issues, feel free to share more details or your dataset (an anonymized sample), and I can assist further!


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